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KMID : 0616120180490030255
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Korean Journal of Pharmacognosy
2018 Volume.49 No. 3 p.255 ~ p.261
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Anti-bacterial and Anti-inflammatory Effects of Angelica dahurica Extracts in Helicobacter pylori-infected Human Gastric Epithelial AGS Cells
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Choi Min-Kyung
Lim Dong-Sool
Choi Sung-Sook
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Abstract
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The aim of this study was to evaluate the anti-helicobacter activity and anti-inflammatory activity of Angelica dahurica (AD). The minimum inhibitory concentration(MIC) of AD against Helicobacter pylori(H. pylori), expression of the H. pylori cagA gene in the presence of AD was determined. Inhibition of H. pylori urease by AD, inhibition of nitric oxide (NO) production in AGS cells was measured. IL-8 mRNA expression in AGS cells which were infected with H. pylori and IL-8 level was measured. The MIC of MeOH Ex. of AD was 250 μg/mL and the expression of cagA gene was decreased about 88% in the presence of AD. The activity of H. pylori urease was inhibited 70% by AD. mRNA expression of IL-8 and the production of NO and IL-8 were significantly decreased in the presence of AD. In conclusion, AD showed anti-Helicobacter activity and has potent anti-inflammatory effect on H. pylori-induced inflammation in human gastric epithelial AGS cells.
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KEYWORD
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H. pylori, Anti-inflammatory, Anti-bacterial, Angelica dahurica, IL-8, AGS cell
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